Regional lymph nodes noticeably increase in size, change their consistency: they become densely elastic and, located nearby, form whole packages - the so-called buboes. Packets of knots are perfectly contoured and bulge significantly under the layer of subcutaneous tissue.

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At the same time, symptoms that are permanent are a decrease in blood pressure, severe cardiac disorders and a sharp tachycardia. Cardiovascular insufficiency is progressive and, in the absence of Topamax treatment, can be fatal. Complex therapy, which is carried out with the active use of antibiotics, first eliminates the effects of intoxication. Then, naturally, an improvement in the activity of the cardiovascular system follows, and then the enlarged regional lymph nodes gradually return to normal. However, sometimes suppuration occurs in the lymph nodes, and they undergo subsequent sclerosis. III. Diagnosis of bubonic plague.

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Epidermolysis bullosa is a large group of hereditary diseases, which are characterized by the formation of blisters on the mucous membranes and skin (spontaneous or under the influence of a minor traumatic effect).

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Depending on the type of disease, epidermolysis bullosa is inherited either in an autosomal dominant or autosomal recessive manner. Mutations can be localized in more than 10 genes. These mutations impair protein synthesis.ecules that provide skin elasticity (collagen, keratin, etc.).

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Depending on the localization of the blisters, the following forms of epidermolysis bullosa are distinguished:

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The pathological process does not affect the lower layers of the skin.

The disease is characterized by the formation of blisters in the oral cavity, thickening of the skin of the soles and palms.

Blisters form at the dermo-epidermal junction.